Maya AV, Neuhaus L, Nogay L, Heckmann L, Singh A, Grass I, Büscher J, Kierdorf K, Classen AK. A JAK/STAT-Pdk1-S6K axis bypasses systemic growth restrictions to promote regeneration. Nature Communications. 2025.
Nogay L, Maya AV, Heckmann L, Cardamone F, Grass I, Singh A, Frey A, Ernst L, Iovino N, Classen AK. Cell cycle dynamics regulate H3K27 and H3K9 histone modifications. Biorxiv.2025
Frey A, Ernst L, Fischer F, Alpar EL, Bellaïche Y, Classen AK. Toll receptors mediate tissue intrinsic surveillance against aberrant cells by detecting cell fate aberrations. Biorxiv.2025
Jahn J, Hofherr A, Consoli C, Fajen B, Goll R, Liedtke GT, Boehm A, Selbach F, Zeisler PC, Weichselberger V, Classen AK, Westermann L, Busch T, Köttgen M. Deep learning-based image quantification of epithelial cell shapes and its application to polycystic kidney disease. Biorxiv.2025
Weichselberger V, Balaji R, Rodriguez-Franco M, Classen AK. The emergence of E-cadherin spot junctions between germline and somatic cells facilitates late stage oogenesis in Drosophila. Biorxiv.2025
Classen, AK. Tumours form without genetic mutations. News and Views. Nature. 2024
Fischer F, Ernst L, Frey A, Holstein K, Prasad D, Weichselberger V, Balaji R, Classen AK. A mismatch in the expression of cell surface molecules induces tissue-intrinsic defense against aberrant cells. Current Biology. 2024
Hersperger F, Meyring T, Weber P, Chhatbar C, Monaco G, Classen AK, Dionne MS, Paeschke K, Prinz M, Groß O, Kierdorf K. DNA damage signaling in Drosophila macrophages modulates systemic cytokine levels in response to oxidative stress. Elife. 2024.
Jaiswal J, Egert J, Engesser R, Peyrotón AA, Nogay L, Weichselberger V, Crucianelli C, Grass I, Kreutz C, Timmer J and Classen AK. Mutual repression between JNK/AP-1 and JAK/STAT stratifies senescent and proliferative cell behaviors during tissue regeneration. PLOS Biology. 2023
Floc’hlay S, Balaji R, Christiaens V, González-Blas CB, De Winter S, Hulselmans G, De Waegeneer M, Quan X, Koldere D, Atkins M, Halder G, Classen AK, Aerts, S. Shared enhancer gene regulatory networks between wound and oncogenic programs. Elife. 2023
Prasad, D, Illek, K, Fischer, F, Holstein, K, and Classen, AK. Bilateral JNK activation is a hallmark of interface surveillance and promotes elimination of aberrant cells. Elife. 2023
Crucianelli, C, Jaiswal J, Maya AV, Nogay L, Cosolo A, Grass I, Classen AK. Distinct signaling signatures drive compensatory proliferation via S-phase acceleration. PLOS Genetics. 2022.
Weichselberger V, Dondl P, Classen AK. Eya-controlled affinity between cell lineages drives tissue self-organization during Drosophila oogenesis. Nature Communications. 2022
Balaji R, Weichselberger V, Classen AK. Response of epithelial cell and tissue shape to external forces in vivo. Development. 2019
Cosolo A, Jaiswal J, Csordás G, Grass I, Uhlirova M, Classen AK. JNK-dependent cell cycle stalling in G2 promotes survival and senescence-like phenotypes in tissue stress. Elife. 2019
La Fortezza M, Grigolon G, Cosolo A, Pinduyrin A, Breimann L, Blum H, van Steensel B, Classen AK. DamID-profiling of dynamic Polycomb-binding sites in Drosophila imaginal disc development and tumorigenesis. Epigenetics and Chromatin. 2018
Schunter S, Villa R, Classen AK, Beli P, Becker P. Ubiquitylation of the acetyltransferase MOF in Drosophila melanogaster. PLOS One. 2017
Balaji R, Bielmeier C, Harz H, Bates J, Stadler C, Hildebrand A, Classen AK. Calcium spikes, waves and oscillations in a large, patterned epithelial tissue. Scientific Reports. 2017
La Fortezza M, Schenk M, Cosolo A, Kolybaba A, Grass I, Classen AK. JAK/STAT signalling mediates cell survival in response to tissue stress. Development. 2016
Bielmeier C, Alt S, Weichselberger V, La Fortezza M, Harz H, Jülicher F, Salbreux G, Classen AK. Interface Contractility between Differently Fated Cells Drives Cell Elimination and Cyst Formation. Current Biology. 2016
Bunker BD, Nellimoottil TT, Classen AK and Bilder D. The Transcriptional Response to Tumorigenic Polarity Loss in Drosophila. Elife. 2015
Kolybaba A, Classen AK. Sensing cellular states – Signaling to chromatin pathways targeting Polycomb and Trithorax group function. Cell and Tissue Research. 2014
Mottola G, Classen AK, González-Gaitán M, Eaton S, Zerial M. A novel function for the Rab5 effector Rabenosyn-5 in planar cell polarity. Development. 2010
Classen AK, Bunker BD, Harvey KF, Vaccari T, Bilder D. A tumor suppressive activity of Drosophila Polycomb genes mediated by JAK/STAT signaling. Nature Genetics. 2009
Kolahi KS*, White PF*, Shreter DM*, Classen AK*, Bilder D, Mofrad MR. Quantitative analysis of epithelial morphogenesis in Drosophila oogenesis: New insights based on morphometric analysis and mechanical modeling. Developmental Biology. 2009
Classen AK, Aigouy B, Giangrande A, Eaton S. Imaging Drosophila pupal wing morphogenesis. Methods in Molecular Biology. 2008
Vogel M, Guelen L, Wit E, Lodén M, Talhout W, Feenstra M, Abbas B, Classen AK, van Steensel B. Human heterochromatin proteins form large domains containing KRAB-ZNF genes. Genome Research. 2006
Classen AK, Anderson K, Marois E, Eaton S. Hexagonal packing of Drosophila wing epithelial cells by the Planar Cell Polarity pathway. Developmental Cell. 2005
Old Biorxiv Preprints (now peer-reviewed and published)
Maya AV, Nogay L, Heckmann L, Grass I, Kierdorf K , Büscher J, Classen AK. PDK-1/S6K and mTORC1 bypass systemic growth restrictions to promote regeneration.Biorxiv. 2024
Hersperger F, Meyring T, Weber P, Chhatbar C, Monaco G, Classen AK, Dionne MS, Paeschke K, Prinz M, Groß O, Kierdorf K. Drosophila macrophages control systemic cytokine levels in response to oxidative stress via a non-canonical DNA damage repair signaling cascade. Biorxiv.2023
Fischer F, Ernst L, Frey A, Holstein K, Prasad D, Weichselberger V, Balaji R, Classen AK. A cell surface code mediates tissue-intrinsic defense against aberrant cells in epithelia. Biorxiv.2023. Our Preprint was highlighted in Development !
Jaiswal, J, Engesser, R, Peyroton, AA, Weichselberger, V, Crucianelli, C, Grass, I, Timmer, J, and Classen, AK. Mutual repression between JNK/AP-1 and JAK/STAT stratifies cell behaviours during tissue regeneration. Biorxiv. 2022
Floc’hlay, S, Balaji, B, Christiaens, V, Bravo González-Blas, C, De Winter, S, Hulselmans, G, De Waegeneer, M, Quan, X, Koldere, D, Atkins, M, Halder, G, Classen, AK and Aerts S. Shared enhancer gene regulatory networks between wound and oncogenic programs. Biorxiv.2022
Weichselberger V, Dondl P, Classen AK. Eya-controlled affinity between cell lineages drives tissue self-organization during Drosophila oogenesis. Biorxiv. 2022
Prasad D, Illek K, Fischer F, Holstein K, Classen AK, Bilateral JNK activation is a hallmark of interface contractility and promotes elimination of aberrant cells. Biorxiv. 2022
Balaji R, Weichselberger V, Classen AK. Regulation of tensile stress in response to external forces coordinates epithelial cell shape transitions with organ growth and elongation. Biorxiv. 2018
Classen Lab 