Epithelial tissues of the skin, gut or lung form a barrier between the external environment and internal tissues. This exposed position makes epithelia susceptible to injury, inflammation, oncogenic transformation and even mechanical perturbations. We investigate how epithelia sense, assess and respond to these processes. We utilize approaches from molecular, cell and developmental biology and combine these with the excellent genetic tools and experimental tractability of the Drosophila system to explore these questions in vivo.

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